Effect of Whole Body Hyperthermia and BCNU on the Development of Radiation Myelitis in the Rat

Abstract
A radiant heat device was used to study the interaction of 41.8.degree. C whole body hyperthermia (WBH), radiation (40 Gy [grays]) and the lipophilic antineoplastic agent BCNU in the development of myelitis in the rat spinal cord. The addition of WBH and BCNU neither precipitated myelitis acutely nor shortened the latency before the onset of neurological signs in irradiated animals.