C-19393 S2 and H2, new carbapenem antibiotics. IV. Inhibitory activity against .BETA.-lactamases.
- 1 January 1981
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 34 (2) , 212-217
- https://doi.org/10.7164/antibiotics.34.212
Abstract
New carbapenem antibiotics, C 19393 S2 and H2, are potent and broad spectrum inhibitors of .beta.-lactamases. Among 11 types of .beta.-lactamases tested, those from Escherichia coli (plasmid-bearing), Klebsiella pneumoniae, Proteus vulgaris, Serratia marcescens and Bacteroides fragilis were especially sensitive. They also inhibited cephalosporinases insensitive to clavulanic acid. The inhibition by C-19393 S2 and H2 was of progressive type, except for the inhibition of E. coli enzyme (plasmid-mediated type I) by C-19393 H2. The inhibition of E. coli .beta.-lactamase by C-19393 S2 was irreversible, while that by C-19393 H2 was reversible.This publication has 3 references indexed in Scilit:
- C-19393 S2 and H2, new carbapenem antibiotics. II. Isolation and structures.The Journal of Antibiotics, 1980
- The inhibition of staphylococcal β-lactamase by clavulanic acidBiochemical Journal, 1979
- Clavulanic Acid: a Beta-Lactamase-Inhibiting Beta-Lactam from Streptomyces clavuligerusAntimicrobial Agents and Chemotherapy, 1977