Introduction to NF-κB: players, pathways, perspectives
Top Cited Papers
- 30 October 2006
- journal article
- review article
- Published by Springer Nature in Oncogene
- Vol. 25 (51) , 6680-6684
- https://doi.org/10.1038/sj.onc.1209954
Abstract
This article serves as an introduction to the collection of reviews on nuclear factor-kappaB (NF-κB). It provides an overview of the discovery and current status of NF-κB as a research topic. Described are the structures, activities and regulation of the proteins in the NF-κB family of transcription factors. NF-κB signaling is primarily regulated by inhibitor κB (IκB) proteins and the IκB kinase complex through two major pathways: the canonical and non-canonical NF-κB pathways. The organization and focus of articles included in the following reviews are described, as well as likely future areas of research interest on NF-κB.Keywords
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