Postoperative Management of Patients with Pheochromocytoma

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Abstract
The optimal preoperative and postoperative management of patients with pheochromocytoma demands a multidisciplinary approach. For 5 recent patients, large volumes of fluid were needed in the early postoperative period. This large fluid requirement was due to a combination of factors, involving a change in vascular compliance after excision of a pheochromocytoma, the residual effects of specific preoperative medications (phenoxybenzamine and .alpha.-methyl-p-tyrosine) and the loss of fluid into the retroperitoneal compartment (3rd space) produced by extensive dissection. It took 3 half-lives (36 h) to dissipate the effects of phenoxybenzamine and .alpha.-methyl-p-tyrosine, which corresponded to the time which these patients required large volumes of i.v. fluids.

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