Protective Effect of Anethol Dithiolthione Against Acetaminophen Hepatotoxicity in Mice
- 1 July 1989
- journal article
- research article
- Published by Wiley in Basic & Clinical Pharmacology & Toxicology
- Vol. 65 (1) , 63-64
- https://doi.org/10.1111/j.1600-0773.1989.tb01127.x
Abstract
Anethol dithiolthione (ADT), usually prescribed as a choleretic drug, when given orally 1 hour prior to acetaminophen (AAP) (450 mg/kg intraperitoneally) in Swiss female mice, exhibited an hepatoprotective potency at doses as low as 10 mg/kg relative to serum aminotransferase activities and hepatic glutathione related enzyme system (glutathione reductase, peroxidase, transferase). These preliminary results are relevant with the use of pharmacologic dosage of ADT in hepatotoxicity prevention.This publication has 9 references indexed in Scilit:
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