INFLUENCE OF INSULIN ON LIVER AND MUSCLE GLYCOGEN IN THE RAT UNDER VARYING NUTRITIONAL CONDITIONS

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Abstract
White rats kept on a selected diet and accustomed to handling were starved for 48 hrs. because muscle glycogen values are more constant than after 24 hrs.'' starvation. Liver glycogen was greater after 48 hrs.'' than after 24 hrs.'' starving; presumably due to accentuation of a process of gly-eoneogenesis developing after depletion of original stores of liver glycogen. Moderate non-convulsive doses of insulin in starved rats (1 to 3 units per kgm.) caused a decrease in liver glycogen in the 1st hr. with a subsequent rise above normal. Muscle glycogen was reduced without evidence of a later increase. When similar moderate doses of insulin were injected in rats 1 hr. after feeding, less liver glycogen was deposited than in controls. Satisfactory evidence of change in muscle glycogen was not obtained. With large doses of insulin (10 units or more per kgm.) the inhibitory effect on deposition of liver glycogen was more marked and there seemed to be a moderate increase in muscle glycogen after 2 hrs. or more following injection of insulin.

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