Skeletal Muscle Metabolism Symposium

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Abstract
Living organisms move freely within their environment. It is a biological marvel that the mobility demands, ranging from postural maintenance to rapid bursts of movement, either at play or for survival, are performed by just one type of organ, namely skeletal muscle. To cope with these wide ranges of demands, exquisitely sensitive and complexly regulated biochemical pathways have evolved to support skeletal muscle energetics. A. V. Hill's challenge to biochemists led to the confirmation of a long-held belief that ATP provides the chemical energy for muscle contraction. However, the reservoir of ATP in muscle is extremely small, and without the continuous synthesis of ATP, muscle contractility would cease in only a few seconds. Therefore, the regulation of substrate metabolism in muscle has been of considerable interest to muscle physiologists and biochemists. In this symposium, five scientists provide a comprehensive review of different aspects of the regulation of skeletal muscle metabolism during increased contractile activity, from work in their laboratories.I would like to thank the Natural Sciences and Engineering Research Council of Canada for its financial support of this symposium.

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