Potentiation of the estrogenic activity of stilbestrol by spiro(cyclohexane-1,2'-indan)-1',4-dione
- 1 March 1976
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 19 (3) , 438-439
- https://doi.org/10.1021/jm00225a024
Abstract
During the investigation of a series of spiro compounds having approximately similar molecular dimensions to naturally occurring estrogens, the novel compound spiro(cyclohexane-1,2'-indan)-1',4-dione was prepared. The pretreatment of mice with this estrogenically inactive compound was found to potentiate the estrogenic activity of stilbestrol.Keywords
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