Immunological Features of Nonimmunogenic Hyperthyroidism*

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Abstract
Blood lymphocyte subpopulations (Leu 4† cells = pan-T cells, Leu 3a† cells = helper/inducer cells, and Leu2a† cells = suppressor/cytotoxic cells), thyroid-stimulating immu-noglobulins, microsomal antibodies and antibodies against thy-roglobulin were determined in 10 patients with hyperthyroidism due to single autonomously functioning thyroid nodules (ATN), 11 patients with hyperthyroidism due to Graves′ disease (GD)and in 20 normal subjects. Thyroidectomy was performed in 8 of the patients with ATN andin 6 of those with GD after 3 weeks of antithyroid drug treatment with methimazole. Lymphocytic infiltration of thyroid tissue, the amount of the various lymphocyte subsets (Leu 4†, Leu 3a†, and Leu 2a† T cellsas well as B† B cells) in the thyroid gland, as well as the expression of the histocompatibility antigen HLA-DR on thyrocytes and intrathyroidal lymphocytes were examined. Blood Leu 4† cells were reduced due to a lack of Leu 2a† cells in patients with ATN and GD when compared to normal subjects. Thyroid-stimulating immunoglobulins were detected in all patients with ATN and GD, but in none of the normal subjects. Lymphocytic infiltration of thyroid tissue was present in patients with ATN and GD. The various lymphocyte subsets in the thyroid gland did not differ between the two patient groups. DR expression on thyrocytes was seen in 6 of the patients operated for ATN and in 5 of those who underwent surgery for GD. Infiltration with DR†-T lymphocytes was found in all thyroid glands investigated. Thus immunological findings usually classified as proof for the au-toimmune origin of GD exist also in patients with ATN. An overlap in the pathogenetic background of both diseases seems possible.