It is difficult to keep one's footing in a stampede and practically impossible to think or plan connectedly during a panic. Therefore, the members of the medical profession as well as the public, who have been caught in the whirlwind sweep of this new medical advance, have lost all sense of proportion, direction and balance whenever the subject of endocrinology is touched on. In spite of the turmoil, real progress can be recorded, often unheard, because of incoherent babble and ballyhoo, which is more vocal than constructive and conservative advances. It has been our effort since 1925 to place the study of functional endocrine disturbances of the female sex organs on a more solid foundation and to devise methods that will permit evaluation of conditions comparable to metabolism determinations. Although our methods are now used in many laboratories throughout this country and abroad, the profession at large has not made