Genetic Association between SORL1 Polymorphisms and Alzheimer’s Disease in a Japanese Population

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Abstract
It has recently been shown that the neuronal sortilin-related receptor (SORL1) plays an important role in the pathogenesis of Alzheimer's disease (AD). To investigate whether variations around the SORL1 gene are associated with AD, 7 single-nucleotide polymorphisms (SNPs) were genotyped using TaqMan technology with 180 AD patients and 130 age-matched controls. Our results confirmed the strong linkage disequilibrium among the 7 SNPs studied. However, our study failed to detect any association between the SNPs and AD. We could not confirm any synergetic interaction between the SNPs and apolipoprotein E in our AD patients either. Further genetic studies are needed to clarify the relationship between the SORL1 gene and AD.

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