The Influence of Corticosteroids on Immunological Responses to Bacterial Infections

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Abstract
A distinction is made between 2 groups of animal species. Those termed cortisone-sensitive are unable to maintain body weight, gamma-globulin synthesis and antibody production under cortisone administration. Their resistance to bacterial infection is depressed or abolished. Those termed cortisone-resistant maintain body weight, gamma-globulin synthesis and antibody production under cortisone administration. Their resistance to bacterial infection is not significantly affected. Rats, mice, rabbits and ferrets are cortisone-sensitive. The Rhesus monkey, guinea pig and man are cortisone-resistant. The confusion in the literature regarding the effect of the hormones of the adrenal cortex on immunity is resolved if this species difference is appreciated.