Adjuvanticity of Synthetic Polynucleotides for Induction of Experimental Allergic Encephalomyelitis in Guinea Pigs
Open Access
- 1 December 1974
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 113 (6) , 1942-1946
- https://doi.org/10.4049/jimmunol.113.6.1942
Abstract
Complexes of polyadenylic acid and polyuridylic acid and complexes of polyinosinic acid and polycytidylic acid in incomplete Freund's adjuvant provide the prerequisite adjuvanticity for induction of experimental allergic encephalomyelitis in guinea pigs sensitized to spinal cord homogenate. The experimental allergic encephalomyelitis-adjuvanticity of these polynucleotide complexes resides in the pyrimidine component of each complex, i.e., polyuridylic acid and polycytidylic acid. These findings are discussed in the light of contemporary views linking viruses and nucleic acids to autoimmune disease of animals and man.Keywords
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