Correlation between Antiinflammatory and Antiproteolytic Properties of Substituted Benzylidenes

Publisher Website
Google Scholar
Abstract
Twelve substituted benzylidenes were evaluated for anti-inflammatory activity against carrageenan-induced edema in rats. The protection afforded by these compounds at a dose of 100 mg/kg, i.p., ranged from 30-60%. Sodium salicylate (100 mg/kg, i.p.), used as a reference drug, exhibited a 30% anti-inflammatory activity under similar experimental conditions. The in vitro effects of substituted benzylidenes were also investigated on the activity of trypsin during hydrolysis of bovine serum albumin, serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase and endogenous lipid peroxide formation by liver homogenates. Some correlation between anti-inflammatory and antiproteolytic properties of substituted benzylidenes was seen.