IN VITROMETABOLISM OF STEROID KETALS

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Abstract
The effects of 3 or 20 ftthylene kotal substituents on adrenoeorticoid metabolism have boon studied in vitro. Ketalization of the 3 position of 9α fluorocortisone significantly reduced metabolism by liver enzymes. Introduction of the ethylene ketal grouping at the C-20 position enhanced steroid disappearance as measured by recovery of isonicotinic acid hydrazide reactive steroid.
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