Direct Evidence for Tumor Necrosis Factor-α Signaling in Arteriogenesis
- 9 April 2002
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation
- Vol. 105 (14) , 1639-1641
- https://doi.org/10.1161/01.cir.0000014987.32865.8e
Abstract
Background— Arteriogenesis serves as an efficient mechanism for flow restoration after arterial occlusion. This process is associated with inflammatory mediators such as tumor necrosis factor-α (TNF-α), although their role in arteriogenesis remains unclear. We hypothesized that arteriogenesis is reduced in mice lacking functional TNF-α or p55 receptor. To test this hypothesis, we developed a novel microsphere-based murine model of hindlimb perfusion measurement.Keywords
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