Naturally Occurring Infections in Untreated and Streptomycin-Treated X-irradiated Mice

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Abstract
Additional evidence of the influence of infection on lethality following radiation is demonstrated in the shortening of the survival time of animals showing certain types of infection at death. Deleting the animals that showed positive cultures at death resulted in an essentially linear relationship between dose and time to death in the dose range 800 to 550 r. Infections were rarely observed in mice that died about 3.5 days after irradiation (1400 and 1100 r) and were most frequently observed in animals that died after 6 to 9 days, with the incidence reduced in those that died in the 3d wk. after irradiation. With streptomycin treatment, although there was not always a significant reduction in mortality, there was always a reduction in the no. of positive blood cultures. Streptomycin treatment resulted in a prolongation of survival time which was independent of the presence of organisms in the blood at death.

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