A NEUTRAL FLUOROGENIC SUBSTANCE IN HUMAN URINE AND ITS INCREASED EXCRETION IN PREGNANCY AND PSEUDOHERMAPHRODITISM

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Abstract
A non-phenolic fraction of urine is obtained by acid hydrolysis, ether extraction, washing with 0.1 [image] NaOH, partition between dilute ethanol and first benzene, then pet. ether, and final extraction from the aqueous ethanol with ether. This material fluoresces after heating at 100[degree]C in 85% H3PO4. It is present in small amts. in normal male and female urine, and is increased in pregnancy. It is increased in female pseudohermaphrodites (2) and in arrhenoblastoma (1); ACTH increases it. Its concn. does not parallel neutral reducing lipids or 17-ketosteroids of urine. It is, however, presumably of adrenal origin.