The pathogenic basis of malaria
Top Cited Papers
- 1 February 2002
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 415 (6872) , 673-679
- https://doi.org/10.1038/415673a
Abstract
Malaria is today a disease of poverty and underdeveloped countries. In Africa, mortality remains high because there is limited access to treatment in the villages. We should follow in Pasteur's footsteps by using basic research to develop better tools for the control and cure of malaria. Insight into the complexity of malaria pathogenesis is vital for understanding the disease and will provide a major step towards controlling it. Those of us who work on pathogenesis must widen our approach and think in terms of new tools such as vaccines to reduce disease. The inability of many countries to fund expensive campaigns and antimalarial treatment requires these tools to be highly effective and affordable.Keywords
This publication has 86 references indexed in Scilit:
- Why is the Pathology of Falciparum Worse than that of Vivax Malaria?Parasitology Today, 1999
- Antibodies that Inhibit Malaria Merozoite Surface Protein–1 Processing and Erythrocyte Invasion Are Blocked by Naturally Acquired Human AntibodiesThe Journal of Experimental Medicine, 1997
- Severe anaemia in children living in a malaria endemic area of KenyaTropical Medicine & International Health, 1997
- Seizures and status epilepticus in childhood cerebral malariaQJM: An International Journal of Medicine, 1996
- The large diverse gene family var encodes proteins involved in cytoadherence and antigenic variation of plasmodium falciparum-infected erythrocytesPublished by Elsevier ,1995
- Indicators of Life-Threatening Malaria in African ChildrenNew England Journal of Medicine, 1995
- Receptor and Ligand Domains for Invasion of Erythrocytes by Plasmodium falciparumScience, 1994
- Rapid switching to multiple antigenic and adhesive phenotypes in malariaNature, 1992
- Molecular Basis of Sequestration in Severe and Uncomplicated Plasmodium falciparum Malaria: Differential Adhesion of Infected Erythrocytes to CD36 and ICAM-lThe Journal of Infectious Diseases, 1991
- The duffy receptor family of plasmodium knowlesi is located within the micronemes of invasive malaria merozoitesCell, 1990