Cyclooxygenase-2 Expression Correlates with Local Chronic Inflammation and Tumor Neovascularization in Human Prostate Cancer
Open Access
- 1 May 2005
- journal article
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 11 (9) , 3250-3256
- https://doi.org/10.1158/1078-0432.ccr-04-2405
Abstract
Purpose: Chronic inflammation is linked to the development of cancer in several organs, including the prostate. Up-regulated cyclooxygenase-2 (COX-2) may play a role in influencing cell proliferation, differentiation, apoptosis, or angiogenesis. This study aimed to derive data from human prostate cancer to investigate whether chronic inflammation and angiogenesis were correlated with the expression of COX-2.Keywords
This publication has 37 references indexed in Scilit:
- Tumor necrosis factor-α stimulates gastric epithelial cell proliferationAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 2005
- Chronic inflammation in benign prostate hyperplasia is associated with focal upregulation of cyclooxygenase‐2, Bcl‐2, and cell proliferation in the glandular epitheliumThe Prostate, 2004
- Analysis of the inflammatory network in benign prostate hyperplasia and prostate cancerThe Prostate, 2003
- Cyclooxygenase-2 as a Potential Target in the Prevention and Treatment of Genitourinary Tumors: A ReviewJournal of Urology, 2003
- Dosage, duration and timing of nonsteroidal antiinflammatory drug use and risk of prostate cancerInternational Journal of Cancer, 2003
- Interstitial cell cyclooxygenase‐2 expression is associated with increased angiogenesis in human sporadic colorectal adenomasThe Journal of Pathology, 2002
- A Population-Based Study of Daily Nonsteroidal Anti-inflammatory Drug Use and Prostate CancerMayo Clinic Proceedings, 2002
- INHIBITION OF CYCLOOXYGENASE-2 SUPPRESSES ANGIOGENESIS AND THE GROWTH OF PROSTATE CANCER IN VIVOJournal of Urology, 2000
- Host cyclooxygenase-2 modulates carcinoma growthJournal of Clinical Investigation, 2000
- Tumor Angiogenesis Predicts Recurrence in Invasive Colorectal Cancer When Controlled for Dukes StagingThe American Journal of Surgical Pathology, 1996