Methionine Interference in Rapamycin Production Involves Repression of Demethylrapamycin Methyltransferase and S -Adenosylmethionine Synthetase

Publisher Website
Google Scholar
Abstract
In a chemically defined medium, l -methionine decreased production of rapamycin and increased that of demethylrapamycin. Growth with l -methionine yielded cells with a lower ability to convert demethylrapamycin to rapamycin and decreased the level of S -adenosylmethionine synthetase and S -adenosylmethionine. Thus, methionine represses at least one methyltransferase of rapamycin biosynthesis and S -adenosylmethionine synthetase.