EFFECT OF SEX HORMONES ON EHRLICH MOUSE ASCITES CANCER

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Abstract
Ehrlich mouse ascites cancer grew better during the first 3 days after inoculation in female than in male mice. The difference was only demonstrable on inoculation with small doses of cancer cells and could not be seen when large doses were used. On the 5th day after inoculation no difference could be observed in the growth of the cancer between males and females. Gonadectomy had no influence on the growth of the cancer. Testosterone inhibited the growth of the cancer in castrated male mice. It had no effect on the growth of the cancer in castrated female mice. Oestradiol did not influence the growth of the cancer in castrated male or female mice. It is noteworthy that the results obtained in a previous investigation on the growth of the Ehrlich mouse ascites cancer in hamsters revealed a hormonal influence which was only discernible in its natural host during the early growth of the cancer and then only after transplantation of a relatively small number of cancer cells.