Quantitative Aspects of Influenza Virus Multiplication

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Abstract
Summary: Both live and inactivated influenza viruses when introduced into the allantoic cavity are distributed at random among the cells. The distribution is independent of the size of the inoculum. A single particle of inactive virus per cell completely prevents the multiplication in that cell of subsequently entering infective heterologous virus. A comprehensive theory is presented by which the regularities of heterologous interference can be predicted. Methods are described by which the number of available cells, the number of interfering particles, cycle time and the operative cyclic increment of virus can be measured.

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