A Simple Chiral Synthesis of the Taxol Side Chain
- 1 January 1992
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1992 (09) , 761-763
- https://doi.org/10.1055/s-1992-21486
Abstract
We report a highly diastereoselective synthesis of (3R,4S)-3-hydroxy-4-phenyl-2-azetidinone (11) using L-threonine as a chiral template. This compound has been utilized in the partial synthesis of taxol from 10-desacetyl baccatin III (2a).Keywords
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