Physiological, biochemical, and morphological characteristics of myocardial anoxia: the use of a semi-perfusion canine preparation
- 1 November 1977
- journal article
- research article
- Published by Oxford University Press (OUP) in Cardiovascular Research
- Vol. 11 (6) , 568-575
- https://doi.org/10.1093/cvr/11.6.568
Abstract
Regional myocardial anoxia was produced in dogs by perfusion of the left circumflex artery (LCA) with deoxygenated blood. Isolated sarcoplasmic reticulum fragments (cardiac relaxing system) showed decreased Ca2+ binding and uptake. The ability of isolated mitochondria to utilise long-chain fatty acids was markedly reduced. This model has revealed inherent biochemical differences between ischaemia and anoxia.This publication has 8 references indexed in Scilit:
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