LOVASTATIN POTENTIATES THE PHOTOCYTOTOXIC EFFECT OF PHOTOFRIN II DELIVERED TO HT29 HUMAN COLONIC ADENOCARCINOMA CELLS BY LOW DENSITY LIPOPROTEIN
- 1 February 1993
- journal article
- Published by Wiley in Photochemistry and Photobiology
- Vol. 57 (2) , 371-375
- https://doi.org/10.1111/j.1751-1097.1993.tb02303.x
Abstract
A 24 h preculture of HT29–18human colonic adenocarcinoma cells with the sterol synthesis inhibitor lovastatin at concentrations of 0.1‐0.5 μM markedly increased the photocytotoxic effect of photofrin II delivered to cells by low density lipoproteins. Under the same conditions, LDL binding and photofrin II (PII) uptake by HT29 cells increased about 1.8‐fold and 1.5‐fold, respectively. These results suggest that hydroxymethylglutaryl‐coenzyme A reductase inhibitors could be useful for potentiating the photodynamic therapy of tumors by PII.Keywords
This publication has 15 references indexed in Scilit:
- Metabolism of low‐density lipoprotein in differentiated and undifferentiated HT29 colon cancer cellsInternational Journal of Cancer, 1990
- Photosensitization of Wi26-VA4 transformed human fibroblasts by low density lipoprotein loaded with the anticancer porphyrin mixture photofrin II: evidence for endoplasmic reticulum alterationCancer Letters, 1989
- Porphyrin-lipoprotein association as a factor in porphyrin localizationCancer Letters, 1986
- In vitro interaction of the photoactive anticancer porphyrin derivative photofrin II with low density lipoprotein, and its delivery to cultured human fibroblastsFEBS Letters, 1986
- Role of high-, low- and very low-density lipoproteins in the transport and tumor-delivery of hematoporphyrin in vivoCancer Letters, 1986
- INTERACTION OF HUMAN SERUM LOW DENSITY LIPOPROTEINS WITH PORPHYRINS: A SPECTROSCOPIC AND PHOTOCHEMICAL STUDYPhotochemistry and Photobiology, 1984
- Evidence for a major role of plasma lipoproteins as hematoporphyrin carriers in vivoCancer Letters, 1984
- OXYGEN DEPENDENCY OF PHOTOCYTOTOXICITY WITH HAEMATOPORPHYRIN DERIVATIVEPhotochemistry and Photobiology, 1984
- The metabolism of very low density lipoprotein proteins I. Preliminary in vitro and in vivo observationsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1972
- THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUMJournal of Clinical Investigation, 1955