BONE AND TISSUE PHOSPHATASE IN EXPERIMENTAL SCURVY AND STUDIES ON THE SOURCE OF SERUM PHOSPHATASE

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Abstract
The phosphatase activity of the tissues of a large group of normal and scorbutic guinea pigs was studied. No significant differences between the phosphatase activity of normal and scorbutic guinea pig intestinal mucosa, kidney, adrenal or liver were observed. The phosphatase activity of bone (tibia) from scorbutic animals is strikingly decreased. In rib the decrease is not so pronounced. With recovery from scurvy, the bone phosphatase is restored to its normal activity. The fall in bone phosphatase activity parallels the fall in serum phosphatase activity and with the adm. of ascorbic acid there is a concomitant rise in the blood and bone phosphatase. The inhibitory effect of bile salts suggests that the small amt. of phosphatase activity remaining in the serum in severe scurvy is not of intestinal origin.

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