A case of EBV-associated lymphoproliferative disease following high-dose therapy and CD34-purified autologous peripheral blood progenitor cell transplantation
- 1 August 1998
- journal article
- case report
- Published by Springer Nature in Bone Marrow Transplantation
- Vol. 22 (3) , 307-309
- https://doi.org/10.1038/sj.bmt.1701335
Abstract
A fatal case of EBV-associated lymphoproliferative disorder arising after a CD34-selected autologous peripheral blood stem cell transplant is reported in a patient with multiple myeloma in first plateau phase. It is suggested that this is likely to be a consequence of the accessory cell depletion associated with the CD34+ cell purification and it is recommended that a source of autologous T cells is stored before transplantation to be used if a severe opportunistic infection or EBV lymphoma arises post-transplantation.Keywords
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