EFFECTS OF PROSTAGLANDINS AND THROMBOXANE ANALOGUES ON BULLOCK AND DOG IRIS SPHINCTER PREPARATIONS

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Abstract
1 The bullock iris sphincter was contracted by low concentrations of prostaglandin E2 (PGE2), 16,16-dimethyl PGE2 and 17,18,19,20-tetranor-16-p-chlorophenoxy PGE2. Other compounds with thromboxane-like actions, for example 11,9-epoxymethano PGH2, were also potent spas-mogens. ZK 36374, a stable carbacyclin, was a partial agonist on the PGE-sensitive system of this tissue. 2 The thromboxane antagonist, EP 045, had little effect on the action of PGE2 and 16,16-dimethyl PGE2 on the bullock iris. 3 The dog iris sphincter was sensitive to PGF2α but not to PGE2 and 11,9-epoxymethano PGH2. 4 16,16-Dimethyl PGE2 had very low activity on the dog iris in contrast to its high activity on the bullock iris. The reverse was found with the 17,18,19,20-tetranor-16-m-trifluoromethylphenoxy analogue of PGF2α (ICI 81008). This indicates a considerable selectivity of action of the two analogues. 5 The results are discussed in relation to the existing knowledge of prostanoid receptors.