Reference Values and Analytical Performance of the Hydroxyproline/Creatinine Ratio in Early Morning Urine Samples

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Abstract
The hydroxyproline/creatinine ratio for 2 groups of healthy individuals and 2 groups of patients with a history of mammary and prostatic carcinoma without metastases was measured and compared with literature values. The hydroxyproline/creatinine ratio for healthy adults appears to be 1.4 (range 0.7-2.3). The influence of diet and gelatin load of 30 g on the hydroxyproline creatinine ratio and the hydroxyproline excretion was investigated. The analytical characteristics of the test were evaluated using the method of standard additions. An intra-assay quality-control on the basis of the standard addition is proposed. The coefficient of variation of the hydroxypyroline/creatinine ratio appears to be 22%. The intraindividual variability was also established for the hydroxyproline/creatinine ratio and appears to be 25%.