Developmental changes in erythropoietin receptor expression of fetal mouse liver

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Abstract
Erythropoietin (EPO) stimulates proliferation and differentiation or late erythroid precursor cells (CFU‐E) and thereby determines the rate of erythropoiesis, Liver is the major erythropoietic site in a fetus. We dealt with developmental changes in CFU‐E and EPO receptor (EPO‐R) of fetal mouse liver. The affinity of the EPO‐R to EPO was unchanged during fetal development. The popupation size of CFU‐E, the number of EPO‐R per liver cell, and EPO‐R mRNA decreased as gestation proceeded, in a pattern indicating that the expression of EPO‐R on erythroid precursor cells in fetal mouse liver is governed mostly by the process of mRNA production.