FETAL MORTALITY ASSOCIATED WITH CLEFT-LIP AND CLEFT-PALATE

  • 1 January 1982
    • journal article
    • research article
    • Vol. 151  (6) , 287-289
Abstract
Analysis of 1516 pregnancies in sibships of probands with cleft lip with or without cleft palate [CL(P)] and 774 pregnancies in those of probands with isolated cleft palate (CP) indicated that fetal mortality significantly increases with liability to clefting. These data are compatible with the multifactorial 2-threshold model, according to which a lower threshold level of liability results in a cleft formation and a higher level of liability causes a fetal death.

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