DRUG INHIBITION OF ECTO-ATPASE AND OF PHAGOCYTOSIS IN LEUKOCYTES

  • 1 January 1976
    • journal article
    • research article
    • Vol. 14  (2) , 277-285
Abstract
Substituted phenothiazines and tricyclic antidepressants which inhibited the ecto-ATPase in [rat] leukocytes markedly decreased the phagocytic activity of these cells. In affecting either the enzyme or phagocytosis the order of potency of the drugs was similar. Various other CNS drugs were ineffective. The results suggest possible involvement of ecto-ATPase in the phagocytic process and indicate adverse effects of the aforelisted drugs on the host defense system against foreign materials, including microbes. Drugs tested include: the tricyclic antidepressants desipramine, imipramine, amitriptyline and nortriptyline; the phenothiazine tranquilizers mesoridazine, promazine, chlorpromazine, perphenazine, trifluoperazine and thioridazine; and other CNS drugs- amphetamine, morphine and phenobarbital.

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