CD4+ but not CD8+T cells are required for the induction of oral tolerance
- 1 March 1995
- journal article
- research article
- Published by Oxford University Press (OUP) in International Immunology
- Vol. 7 (3) , 501-504
- https://doi.org/10.1093/intimm/7.3.501
Abstract
It has been suggested that oral tolerance is mediated by CD8+ T lymphocytes, but the functional properties of these cells are unclear. Here we show that the induction of tolerance by feeding mice ovalbumin (OVA) does not prime antigen-specific class I MHC-restricted cytotoxic T cells in vivo. Indeed, such responses are markedly suppressed in mice fed OVA, and the induction of oral tolerance is abolished by depletion in vivo of CD4+ but not CD8+ T cells. These results indicate that CD8+ lymphocytes are unlikely to play a major role in the induction of oral tolerance and are the first demonstration that specific cytotoxic responses to an exogenous antigen can be suppressed by feeding antigen.Keywords
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