Appetite Suppressants and Valvular Heart Disease

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Abstract
The populations of industrialized nations are becoming steadily more overweight as a result of changes in physical activity and diet. In recent years, concern about health and appearance has led ever-increasing numbers of people to use a wide variety of diets, dietary aids, and exercise regimens to lose weight. In this regard, the prospects of successfully losing weight with the help of appetite-suppressant medication appeared to improve with the publication in 1992 of reports showing the efficacy of fenfluramine and phentermine in combination1,2 and in 1996 with the approval by the Food and Drug Administration (FDA) of dexfenfluramine, the . . .