[3H]‐tetracaine binding on rat synaptosomes and sodium channels
Open Access
- 1 September 1985
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology
- Vol. 86 (1) , 125-129
- https://doi.org/10.1111/j.1476-5381.1985.tb09442.x
Abstract
1 [3H]-tetracaine binding was studied in a rat synaptosomal preparation. [3H]-tetracaine bound to a single class of binding sites with a mean KD of 188 ± 28 nM and a mean maximal binding capacity of 13 ± 0.7 pmol mg−1 protein. 2 [3H]-tetracaine binding was inhibited by tetracaine, procaine and by β-adrenoceptor blocking agents which possess local anaesthetic properties. 3 [3H]-tetracaine binding was not modified by neurotoxins interacting specifically with the sodium channels.This publication has 24 references indexed in Scilit:
- Local anaesthetic activity of organic calcium antagonists: relevance to their actions on smooth muscleEuropean Journal of Pharmacology, 1982
- A cardiac tetrodotoxin-binding component: biochemical identification, characterization, and propertiesBiochemistry, 1981
- Neurotoxins that Act on Voltage-Sensitive Sodium Channels in Excitable MembranesAnnual Review of Pharmacology and Toxicology, 1980
- Binding of sea anemone toxin to receptor sites associated with gating system of sodium channel in synaptic nerve endings in vitro.Proceedings of the National Academy of Sciences, 1980
- Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.The Journal of general physiology, 1977
- The binding of saxitoxin and tetrodotoxin to excitable tissuePublished by Springer Nature ,1977
- Inhibition of sodium currents in frog ranvier node treated with local anesthetics Role of slow sodium inactivationBiochimica et Biophysica Acta (BBA) - Biomembranes, 1976
- The binding of labelled saxitoxin to the sodium channels in nerve membranesThe Journal of Physiology, 1973
- On the Mode of Action of Local AnestheticsAnnual Review of Pharmacology, 1966