Ecalectin/Galectin-9, a Novel Eosinophil Chemoattractant: Its Function and Production
- 1 May 2000
- journal article
- review article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 122 (Suppl. 1) , 6-9
- https://doi.org/10.1159/000053623
Abstract
We have recently succeeded in purifying and cloning a novel eosinophil chemoattractant, ecalectin/galectin-9, which belong to a rapidly growing galectin family. The eosinophil chemoattractant activity of ecalectin is potent and selective for eosinophils. The cellular source of ecalectin has been thought to be antigen-stimulated T cells. Herein, we will review the significance of its divalent galactoside-binding activity in ecalectin-induced eosinophil chemoattraction and the regulation of ecalectin expression in immune cells.Keywords
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