Abstract
The second millennium is over. The editors of the Journal first thought to ignore this passage. After all, the changing of the millennium would undoubtedly be the subject of incessant media attention. Why should we add to it? Yet, looking back, it is hard not to be moved by the astounding course of medical history over the past thousand years. No one alive in the year 1000 could possibly have imagined what was in store. Furthermore, medicine is one of the few spheres of human activity in which the purposes are unambiguously altruistic — in itself, a remarkable achievement.We . . .

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