Therapeutic Targeting of the Hedgehog-GLI Pathway in Prostate Cancer
- 15 April 2005
- journal article
- review article
- Published by American Association for Cancer Research (AACR) in Cancer Research
- Vol. 65 (8) , 2990-2992
- https://doi.org/10.1158/0008-5472.can-05-0439
Abstract
The Hedgehog-GLI signaling pathway is important in animal development and tumorigenesis. Recent findings indicate that the growth and survival of human prostate cancer cells rely upon sustained signaling from the Hedgehog-GLI pathway. These findings have prompted a novel rational strategy for therapeutic treatment of prostate tumors, including metastatic tumors.Keywords
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