Migration inhibition factor and blast transformation in human lymphoid cultures stimulated by different agents.

  • 1 September 1974
    • journal article
    • Vol. 18  (1) , 141-8
Abstract
Macrophage inhibition factor (MIF) like substances were found in the supernatants of human lymphoid cultures stimulated by concanavalin A, tuberculin and allogeneic lymphocytes. These agents are usually regarded as elective stimulators of T lymphocytes. No such a phenomenon was shown when lymphocytes were stimulated by lipopolysaccharide or by goat anti-human F(ab')2 serum, which are known as preferential B-cell stimulators.