Hypergammaglobulinemia and autoantibody induction mechanisms in viral infections
- 10 March 2003
- journal article
- research article
- Published by Springer Nature in Nature Immunology
- Vol. 4 (4) , 343-349
- https://doi.org/10.1038/ni911
Abstract
Polyclonal hypergammaglobulinemia is a characteristic of chronic inflammatory conditions, including persisting viral infections and autoimmune diseases. Here we have studied hypergammaglobulinemia in mice infected with lymphocytic choriomeningitis virus (LCMV), which induces nonspecific immunoglobulins as a result of switching natural IgM specificities to IgG. The process is dependent on help from CD4+ T cells that specifically recognize LCMV peptides presented by B cells on major histocompatibility complex class II molecules. Thus, hypergammaglobulinemia may arise when specific helper T cells recognize B cells that have processed viral antigens irrespective of the B cell receptor specificity. This nonspecific B cell activation may contribute to antibody-mediated autoimmunity.Keywords
This publication has 34 references indexed in Scilit:
- Complement deficiency and autoimmunityCurrent Opinion in Pediatrics, 1998
- Disruption of the Cr2 Locus Results in a Reduction in B-1a Cells and in an Impaired B Cell Response to T-Dependent AntigenPublished by Elsevier ,1996
- Involvement of CD4+Cells in Lymphocytic Choriomeningitis Virus-Induced Autoimmune Anaemia and HypergammaglobulinaemiaJournal of Autoimmunity, 1994
- Escape of Thymocytes and Mature T Cells from Clonal Deletion Due to Limiting Tolerogen Expression LevelsCellular Immunology, 1994
- Functional Role of Type I and Type II Interferons in Antiviral DefenseScience, 1994
- Immune Response in Mice that Lack the Interferon-γ ReceptorScience, 1993
- Disruption of the murine IL-4 gene blocks Th2 cytokine responsesNature, 1993
- Interleukin 6 and plasma cell neoplasiasProgress in Growth Factor Research, 1989
- PERSISTENT GENERALIZED LYMPHADENOPATHY: CLINICAL CHARACTERISTICS OF A LYMPHADENOPATHY SYNDROME IN INTRAVENOUS DRUG ABUSERSAIDS Research, 1986
- Therapy with monoclonal antibodies by elimination of T-cell subsets in vivoNature, 1984