3-Methoxy-4-hydroxymandelic acid excretion during physical exercise.

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Abstract
The relationship of the demands of muscular exercise to urinary catecholamine excretion was explored in 19 men varying in age from 21 to 28 years, after 2. 5 hr. of normal activity and after a 2nd 2. 5-hr. period, the 1st portion of which included graded treadmill exercise. Each subject was given 5. 0 ml/kg water to drink immediately before and again immediately after the work performance. The subjects performed the Balke physical working capacity test to determine their peak O2 intake. Thereafter, following a 10 min. rest period, they worked for 45 min. at an energy expenditure which approximated 50% of their peak aerobic work capacity. Respiratory gas exchange was determined every 15 min. 3-methoxy-4-hydroxymandelic acid (VMA) concentrations were determined on the control and exercise urine specimens. The results revealed statistically significant increases of the VMA excretion in all exercise specimens varying from 9. 0 to 98. [mu]g/hr. A statistically significant linear relationship (P < 0.05) between the level of energy expenditure and the quantity of catecholamines excreted during work performance was established.