Aspergillosis of the brain and paranasal sinuses in immunocompromised patients: CT and MR imaging findings.

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Abstract
With the increased survival of patients with severe immunosuppression, it has become more important to recognize the various forms of cerebral and craniofacial aspergillosis. Currently, only small series of patients with this infection have been described; the radiographic diagnosis of cerebral and craniofacial aspergillosis has varied and has been relatively nonspecific. The purpose of our study was to identify neuroimaging patterns in patients with cerebral and craniofacial aspergillosis. Recognition of radiographic patterns of aspergillosis may facilitate earlier radiologic diagnosis and prompt therapy.The imaging and clinical data of eight immunosuppressed patients with cerebral aspergillosis and one patient each with aspergillosis of the orbit, paranasal sinus, and calvaria were evaluated retrospectively. All patients were at risk of developing infection by virtue of poorly controlled diabetes or other types of congenital or acquired immunosuppression (e.g., steroids, chemotherapy). Patients were sel...

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