Experimental intracranial aneurysms in rats

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Abstract
Experimental cerebral aneurysms were induced in rats in which the left carotid artery was ligated. The rats were rendered hypertensive by the Goldblatt procedure, and fed a diet containing .beta.-aminopropionitrile. These intracranial aneurysms have significant gross and microscopic similarities to human berry aneurysms. This experimental model could be useful for studying the development, pathophysiology and therapy of saccular aneurysms.