Increased α1 receptor density in brown adipose tissue of cafeteria-fed rats
- 1 October 1984
- journal article
- research article
- Published by Portland Press Ltd. in Bioscience Reports
- Vol. 4 (10) , 851-859
- https://doi.org/10.1007/bf01138167
Abstract
A possible general corollary between α1-receptor density in brown adipose tissue and the degree of activation of the tissue was investigated. For this purpose, the effect of cafeteria feeding on α1-adrenergic receptors in brown adipose tissue of seven-week-old female rats was studied by the use of the α1-antagonist (3H)prazosin. In cafeteria-fed rats, the KD of the α1-receptor for (3H)prazosin was unchanged (about 0.35 nM), but the receptor density was doubled (up to 40 fmol per mg of membrane protein). This was also observed when the results were expressed per unit of a plasma-membrane marker (5′-nucleotidase). It was concluded that an increased α1-receptor density is seen not only in cold-acclimated rats, but also in other conditions where brown fat is activated, and a possible general physiological significance of α1-adrenergic pathways in brown adipose tissue is discussed.Keywords
This publication has 24 references indexed in Scilit:
- Parallel increases in amount of (3H)GDP binding and thermogenin antigen in brown-adipose-tissue mitochondria of cafeteria-fed ratsBiochemical and Biophysical Research Communications, 1984
- α-Adrenergic effects on 86Rb+(K+) potentials and fluxes in brown fat cellsBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1984
- Na+‐dependent, α‐adrenergic mobilization of intracellular (mitochondrial) Ca2+ in brown adipocytesEuropean Journal of Biochemistry, 1984
- Exclusive occurrence of thermogenin antigen in brown adipose tissueFEBS Letters, 1982
- Responses to cafeteria feeding in mice after the removal of interscapular brown adipose tissueBioscience Reports, 1982
- Decreased guanine nuleotide binding and reduced equivalent production by brown adipose tissue in hypothalamic obesityFEBS Letters, 1982
- Effect of Diet and Cold Exposure on Norepinephrine Turnover in Brown Adipose Tissue of the RatJournal of Clinical Investigation, 1982
- Increased proton conductance pathway in brown adipose tissue mitochondria of rats exhibiting diet-induced thermogenesisNature, 1980
- A role for brown adipose tissue in diet-induced thermogenesisNature, 1979
- THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONSAnnals of the New York Academy of Sciences, 1949