Local cerebral glucose utilization in the symptomatic thiamine‐deficient rat
- 1 August 1982
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 32 (8) , 808
- https://doi.org/10.1212/wnl.32.8.808
Abstract
Local cerebral glucose utilization (LCGU) was measured in asymptomatic rats on a thiamine (B1)-dencient diet for 70 days and in symptomatic fats on a B1-deficient diet for 98 days. LCGU increased in postcommissural fornix (F), pyramidal tracts (P), and inferior internal capsule (CAI) of symptomatic, compared with asymptomatic B1-deficient rats but decreased in thalamic nuclei, auditory structures, and lesioned vestibular nuclei. B1administration to symptomatic rats improved symptoms; decreased LCGU in F, P, and CAI; increased LCGU in the lesioned vestibular nuclei; but decreased LCGU in mammillary nuclei, anteroventral nucleus of thalamus, and medial raphe. The results indicate that B1 deficiency symptoms correlate with LCGU changes in F and P and vestibular nuclei.This publication has 1 reference indexed in Scilit: