The application of statistical moment theory to the evaluation ofin vivo dissolution time and absorption time
- 1 October 1980
- journal article
- Published by Springer Nature in Journal of Pharmacokinetics and Biopharmaceutics
- Vol. 8 (5) , 509-534
- https://doi.org/10.1007/bf01059549
Abstract
Moments analysis has been applied to the calculation of mean (in vivo)dissolution time (MDT) and mean absorption time (MAT) from plasma level of drug versus time data. Methods for accurately estimating the MDT under varying conditions, limitations of the methods, and interpretation of the data are presented. The importance of accurate estimates of the terminal rate constant (λ z) and the drug concentration at the time of withdrawing the final plasma sample (Ĉz)is emphasized in connection with extrapolation to t=∞.The appropriate use of a logarithmic trapezoidal equation for calculating the area under the moments curve (AUMC) is shown to increase the accuracy of estimating MDT.Keywords
This publication has 11 references indexed in Scilit:
- Symbols in pharmacokineticsJournal of Pharmacokinetics and Biopharmaceutics, 1980
- Noncompartmental Determination of the Steady‐State Volume of DistributionJournal of Pharmaceutical Sciences, 1979
- Statistical moments in pharmacokineticsJournal of Pharmacokinetics and Biopharmaceutics, 1978
- Kinetics of acetaminophen absorption and gastric emptying in manClinical Pharmacology & Therapeutics, 1978
- Theory of the mean absorption time, an adjunct to conventional bioavailability studiesJournal of Pharmacy and Pharmacology, 1978
- Pharmacokinetic parameters estimated from intravenous data by uniform methods and some of their usesJournal of Pharmacokinetics and Biopharmaceutics, 1977
- Determination of Common Parameters of Iodothyronine Metabolism and Distribution in Man by Noncompartmental AnalysisJournal of Clinical Endocrinology & Metabolism, 1975
- Letters to the Editor: Linearization of dissolution rate curves by the Weibull distributionJournal of Pharmacy and Pharmacology, 1972
- Input-Output Analysis for Total Input Rate and Total Traced Mass of Body Cholesterol in ManCirculation Research, 1969
- A Statistical Distribution Function of Wide ApplicabilityJournal of Applied Mechanics, 1951