Interferon Pretreatment Regulates Interferon and Interleukin-6 Production in L929 Cells in a Coordinated Manner
- 1 February 1992
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Interferon Research
- Vol. 12 (1) , 13-16
- https://doi.org/10.1089/jir.1992.12.13
Abstract
Two sublines of L929 cells with different interferon (IFN)-producing capacities synthesized IFN and interleukin-6 (IL-6) simultaneously in response to Sendai virus infection. IFN pretreatment primed the production of both cytokines. However, the difference in IL-6 production between the "high and low producer" L-cell sublines was about one magnitude of order larger than in the case of their IFN production. The determination of the corresponding mRNA levels also reflected this difference.Keywords
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