PAPAVERINE HYDROCHLORIDE AND VENTRICULAR FIBRILLATION

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Abstract
Papaverine hydrochloride, in addition to being a powerful coronary vasodilator, also considerably decreases the ease with which ventricular fibrillation is induced in the dog by faradic stimulation. In its presence, vigorous massage of the heart restores a regular synergic beating to ventricles in fibrillation. These actions of the drug permit its application therapeutically and prophylactically, not only where marked protracted coronary dilatation is desirable but also in conditions which are apt to lead to ventricular fibrillation.