A highly efficient approach to prostaglandins via radical addition of α side-chains to methylenecyclopentanones. Total synthesis of natural PGE1, limaprost and new prostaglandin derivatives.
- 1 October 1993
- journal article
- Published by Elsevier in Tetrahedron Letters
- Vol. 34 (40) , 6427-6430
- https://doi.org/10.1016/0040-4039(93)85062-2
Abstract
No abstract availableKeywords
This publication has 14 references indexed in Scilit:
- Stereoselective formation of E- or Z-exocyclic alkenes via radical cyclization reactions of acetylenic estersThe Journal of Organic Chemistry, 1992
- Synthesis of Allyl Ester of Prostaglandin E and the Conversion of the Allyl Ester Moiety into Carboxylic Acid by Chemical Method. A Highly Practical Synthesis of Natural PGE1 and LimaprostChemistry Letters, 1992
- A practical synthesis of the ω side-chain unit present in mexiprostil and its use for synthesis of mexiprostil via two-component coupling process.Tetrahedron: Asymmetry, 1991
- Highly efficient synthesis of 13-dehydroprostaglandins by 1,4-addition reaction of alkynyl .omega. side-chain unit onto a cyclopentenone frameworkThe Journal of Organic Chemistry, 1991
- A highly practical synthesis of natural PGE1, Δ2-trans-PGE1 and 2,2,3,3-tetradehydro-PGE1 via two-component coupling process using zinc-copper reagentsTetrahedron Letters, 1990
- Prostaglandin synthesis via two-component coupling. Highly efficient synthesis of chiral prostaglandin intermediates 4-alkoxy-2-alkyl-2-cyclopenten-1-one and 4-alkoxy-3-alkenyl-2-methylenecyclopentan-1-oneThe Journal of Organic Chemistry, 1988
- Prostaglandin Syntheses by Three‐Component Coupling. New Synthetic Methods (49)Angewandte Chemie International Edition in English, 1984
- Some pharmacological effects of 17(S) methyl-ω-honiytrans-Δ2-PGE1 (ONO 1206)Prostaglandins and Medicine, 1981
- Stereo-controlled synthesis of dl-prostaglandins F2.alpha. and E2Journal of the American Chemical Society, 1969
- Synthesis of prostaglandin F1.alpha. and related substancesJournal of the American Chemical Society, 1969